
Just call me Hestia–the Homeschooler
1. My winter ‘funk/blues’ (you know, the one I’ve been in for about a year and a half) is almost over. I’ve been practicing my hitch kicks and have planned to make a small chocolate cake with buttercream icing to celebrate. (after Lent of course)
2. I’m working on a guest post about homeschooling (yes the same one I’ve been working on for a month) and I was hoping my ‘funk’ would be over before I needed to submit the post. As fate would have it, the funk will still be in place…..which means I’ll need extra special audio-visuals to ensure the ‘readers’ what a wonderful homeschooler I am. Any ideas? Oh wait, dummy me turned the comments off.
3. Never ask a homeschooler to do a guest post anywhere near February…..when most of us are looking for the nearest school that serves lunch…..and hasn’t had a shooting….in a while.
4. I cannot bear to tell anyone of my lenten discipline (other than closing my comments) …..because that would ensure me ‘breaking’ it within the hour. I’ve already considered opening comments back up. I’m just that disciplined.
5. I have renamed myself Hestia-the greek goddess of hearth and home. I’m having new cards printed with my new name and am working on new monograms. Cindy, who made my beef stew, assures me that I qualify. And I’ve always been jealous of “H” monograms.
6. I can’t decide if I want Stevie to be Apollo (god of light) or Helios (god of the son) or Zeus (king of the gods). I could be speaking out of turn, but I think he would also nominate me for Demeter (goddess of grain) because I bake so much bread.
7. There is something ‘to’ this classical education thing. The girls and I are reading about Odysseus, Greek mythology, the Trojan War, Alexander the Great, and even Plato. We’re listening to Bach’s Mass in B minor and memorizing EVERYTHING…..lately we’ve memorized a list of the greek gods, Deut. 6:4-9, the Ten commandments, and the poem Foreign Lands by Robert Louis Stevenson. We’ve read great books like Eight Cousins and The Railway Children. We’ve done some fun art projects including making an Olympic wreath and a cardboard version of The Wooden Horse. We’re studying the life of Christ for lenten devotions and have adopted ‘kneeling’ for our morning prayers. (which Emme was enraged by…..and with a big sigh said, “My knee hurts, mom”. ) My struggles over the past month with homeschooling have been real and grueling. And yet, when I look at some of the wonderful things we’ve done, I can only cry out, “Lord give me strength”. I say all that to say……..pray that I will make the right decisions regarding my childrens’ future.
8. I’m checking out a new program called Classical Conversations. It’s an adjunct for homeschoolers (like a co-op of sorts) and meets once a week in Knoxville. Email me if you have any advice or experience with this program.
9. To take a small break from the Greeks and to help me with my bookclub book for March which is the autobiography of Ben Franklin, I started a book called Founding Brothers. Very interesting, so far. I also plan to read a C.S. Lewis book a month. March-The Great Divorce. Read it with me. You’ll love it. This will be my 3rd time reading it. And I just placed an Amazon order today that will secure for me every last book that Lewis wrote. Oh yes I did.
10. My prayer life reminds me of that of a 4 year old. I start out with the best intentions:
Dear Lord, I confess to you that I am a sinner through and through. I’ve sinned against you in so many large and small ways already today. I’m a beggar in need of repentance and I pray that you will have mercy on me……..(wonder how that gargantuan ball of dog hair/dust got way over there……and I really should take that dog to get him groomed…he’s so cute…that Hank……)
Oh and yes Lord, please forgive me for my lack of attention….where was I? Oh yeah, a poor miserable sinner…..I haven’t even written my thank you note to Aunt Rosemary. (It was so nice of them to have us there last weekend. I don’t know how Uncle Troy made those pepper mills.) And on and on until I almost laugh at how…..childish I must seem to God. I’m like my 6 year old who starts to tell me about what she wants for her birthday and twenty minutes later is asking if I remember that time that she had a bad dream about a monkey driving a big car? This my friends, is why I need Lent. I need discipline and practice and a timeframe.
10. I’m planning a small Greek Festival for the girls and I to ‘showcase’ our favorite Greek projects. We’re gonna make Greek food and wear flowing simple gowns. Okay the girls refuse to wear gowns and will likely not enjoy the food. But I am gonna enjoy it. And very soon I will re-emerge from my ‘funk or whathaveyou’ a new, lighter, and able to breath easier mama. I just know I will.
11. Marcus moves out this Friday. We are sad for us and happy for him. He’s moving to live very near campus which will save a lot of driving time for him. To ease the pain of the transition for the little girls, I told them they could move upstairs to ‘his’ room sometime after he moves out. Which I already regret….’cause they seem too young still (6,8) to not be right beside us. This would however open up their room to me for an office/craft room/lock myself in and cry room. This means I’ve got work to do. Things to paint. Redecorranging galore. Any fresh ideas? My mind is whirling. My heart rate is 180. And I haven’t even had an energy drink yet. And Marcus, we miss you already, despite the fact that the girls keep coming upstairs to ‘scout out the place’.
12. I need a teacher’s aide. Or a cleaning lady. Or a year’s supply of energy drinks. Or all of the above.
13. If you have never heard a 6 and an 8 year old sittin’ around talkin’ about what they’re gonna *do* for Lent, then you should try it sometime. Oh.my.word. Funny stuff. Very funny stuff. And let’s just say that Elea is oiling up her bicycle chain.
14. Maybe I should start a blog carnival called ‘Hooray for Hestia’ or ‘I am a Goddess’ where we women could post random stuff about our home and hearth and share it with others. And then again maybe I need sleep. Or chocolate.


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But it is not really synthetic—it’s derived
instantly from a protein that is found in the human gut.
It is principally one a half of a protein that’s naturally produced in the digestive
system [4]. This guide will explain everything that
researchers should find out about BPC-157 together with its purported
benefits, unwanted effects, and its link to cancer.
Determine 1D reveals that IL-1β induces fast phosphorylation of ERK1/2, JNK and
p38 in Caco2-BBE cells. Nonetheless, co-treatment with KPV strongly
decreased IL-1β-induced MAPK phosphorylation and, therefore, their activation (Figure
1D). Nevertheless, it is essential to note that while research on KPV’s potential advantages is ongoing, it may be extensively obtainable as a
therapeutic agent later. As with any experimental therapy, additional research,
together with medical trials in people, would be wanted to totally understand its security and efficacy.
KPV’s potential is additional backed by patents
detailing its use in treating dermatological issues and beauty conditions.
Though human PepT1 is not expressed in regular colonic epithelial cells (10, sixteen, 17),
we detected its expression at the apical membrane of epithelial cells in chronically infected colon (17).
Apparently, we’ve also proven that immune
cells, similar to macrophages, which are in shut contact with the lamina
propria of the intestine, additionally categorical PepT1 at their membranes (17, 18).
KPV, a potent anti-inflammatory peptide, has garnered significant interest within the remedy of inflammatory bowel ailments (IBD)
similar to Crohn’s disease and ulcerative colitis. These continual conditions
are characterised by persistent inflammation of the gastrointestinal tract, leading to symptoms like abdominal ache,
diarrhea, and fatigue. KPV’s capacity to modulate the
immune response and scale back inflammation makes it a
promising therapeutic candidate for managing these debilitating ailments.
KPV targets main pathogens known as the immune response and cut back
inflammation makes it a promising therapeutic candidate for managing these debilitating
illnesses. When considering the purchase of KPV peptide,
it’s essential to know its therapeutic potential and benefits.
The peptide has proven efficacy in treating skin circumstances
such as psoriasis and zits by reducing inflammation and
accelerating the therapeutic process. Its ability to
reinforce skin well being extends past beauty benefits, providing therapeutic reduction for sufferers affected by continual pores and skin problems.
This has led to increased interest in KPV as a versatile therapy choice in both scientific and aesthetic dermatology.
Another research investigated the anti-inflammatory results of KPV in TNBS-induced colitis
models. The results showed that KPV considerably decreased weight reduction, MPO
exercise, and pro-inflammatory cytokine levels within the colon. These findings
have been further supported by real-time RT-PCR analyses,
confirming the tripeptide’s capacity to mitigate inflammation in vivo.
KPV’s stereoisomer, KdPV, was additionally shown to suppress
LPS-induced NF-κB activation in rat alveolar cells.
Other related peptides and stereoisomers
show weaker anti-inflammatory exercise than KPV.
In Contrast to BPC-157 and TB-500, KPV focuses extra on immune steadiness and cytokine
regulation, making it a novel candidate in inflammatory analysis.
Whereas BPC-157 and TB-500 enhance vascularization and cellular migration, KPV is extra
directly concerned in modulating immune responses, decreasing pro-inflammatory cytokines, and supporting epithelial barrier integrity.
These differences make KPV particularly relevant in analysis on inflammatory bowel diseases,
chronic wounds, and systemic inflammatory conditions.
The price of peptide injections can vary widely
relying on the precise peptide, dosage, remedy length, and healthcare provider.
Prices can range from tons of to 1000’s of dollars
per treatment course to struggle irritation.
We know this due to a 2008 systematic review the place 37 animal studies compiled between 1981 and 2008 showcase
the constant anti-inflammatory results of α-MSH.
Much of what we know about this peptide comes largely from in vivo studies, in vitro studies, animal research, a
couple of small human trials, 4-5 biohackers at most, and fewer peptide physicians.
In other words, you’ll repair inflammation but at the
cost of getting a darker pores and skin tan, which occurs as a end result of stimulated release of melanin (the skin-darkening pigment) by cells situated in the pores and skin (melanocytes).
Common readers of my website will immediately recognize α-MSH because the therapeutic peptides Melanotan I and Melanotan II
are synthetically derived from it.
After appreciable endeavors, sipuleucel-T stands alone as the immunotherapeutic
agent that has yielded a significant survival
benefit in a randomized Phase 3 scientific trial (Kantoff et al., 2010).
The complexity of its administration, its high price, and provide constraints
because of restricted manufacturing capabilities have all contributed to its prescription challenges (Jarosławski and Toumi, 2015).
Your shortcut to trusted peptide insights.We filter out the noise and give you clear, science-based updates and practical
suggestions from the peptide group. Cells had been treated with histidine tagged-KPV and 10ng.ml-1 TNFα for 3h as indicated.
Let’s dive into some innovative therapies for Crohn’s and
ulcerative colitis. Amongst the emerging therapies, Dr. Kim Crawford highlights using specific peptides that have shown promising
results. These peptides embrace GHK-Cu and BPC-157, each known for
their potential regenerative and therapeutic properties.
Furthermore, KPV’s capability to modulate immune system responses and reduce
nitric oxide manufacturing provides one other layer to its anti-inflammatory perform.
By targeting these necessary intracellular signaling pathways, KPV supplies a
multi-faceted strategy to combating inflammation in analysis.
This not solely highlights its potential in peptide remedy analysis but also emphasizes the necessity for additional
research to completely perceive its capabilities. The mechanism of KPV peptide involves selling cell proliferation, collagen synthesis, and modulating
inflammatory responses, which collectively aid in healing wounds, gut health, and doubtlessly treating inflammatory diseases.
By improving gut health, KPV can have a positive influence on overall well-being.
Moreover, its role in sustaining gut health and therapeutic wounds contributes to its effectiveness in treating inflammatory illnesses.
The ability of KPV to advertise therapeutic wounds makes it a useful peptide
in each anti microbial medical and research settings.
References:
https://www.appleradish.org
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References:
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